Talk to your doctor. Ask about AMITIZA.
Full Prescribing Information Important Safety Information For Healthcare Providers Espanol

Talking to Your Doctor

Preparing for Your Doctor Visit

Your doctor is there to help you, but no one knows what you are going through as well as you do. So, make the most of each healthcare provider visit, prepare to describe your situation as thoroughly and accurately as possible.
Tips on preparing for the visit

Symptom Tracker

This tool can help you track your symptoms to help better prepare for your visit.
Learn more about the Symptom Tracker

Tips for a Healthy Conversation

Once you are in the healthcare provider's office, you may find it embarrassing or difficult to discuss your bowel habits. That's normal. Just remember, your healthcare provider has conversations with many other patients. But to get the most from your visit you need to provide your healthcare provider with the best possible description of your symptoms, your responses to therapies, and how constipation affects you.
Tips for discussing Chronic Constipation

Treatment Conversation Guide

This tool can guide you during your conversation with your healthcare professional.
Learn more about the Treatment Conversation Guide

Locate a Doctor

This service can help you find a healthcare provider who can help assess your constipation symptoms and determine the appropriate treatment for you.
Learn more

Important Safety Information

AMITIZA (lubiprostone) is not for everyone. If you know or suspect you have a bowel blockage, do not take AMITIZA. If you are unsure, your healthcare provider (HCP) should evaluate your condition before starting AMITIZA. You should not take AMITIZA if you have severe diarrhea.

Some patients taking AMITIZA may experience nausea or diarrhea. If nausea occurs, take AMITIZA with food and water, if it becomes severe, tell your HCP. If your diarrhea becomes severe, stop taking AMITIZA and tell your HCP.

Within an hour of taking AMITIZA, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use. Tell your HCP if you experience these symptoms.

The most common side effects of taking AMITIZA (24 mcg) twice daily are nausea, diarrhea, headache, abdominal pain, abdominal distension, and gas for patients treated for CIC; nausea and diarrhea for patients treated for Opioid-Induced Constipation. The most common side effects of taking AMITIZA (8 mcg) twice daily for IBS-C are nausea, diarrhea, and abdominal pain. These are not all the side effects associated with AMITIZA.

Tell your HCP if you are taking a diphenylheptane opioid (e.g., methadone).

AMITIZA has not been studied in pregnant women. Based on animal studies, AMITIZA may cause fetal harm. AMITIZA should only be used during pregnancy if the potential benefits justify the potential risk to the fetus. If you are pregnant or become pregnant while being treated with AMITIZA, talk to your HCP to evaluate the risks to the fetus. Tell your HCP if you are nursing and monitor infants for diarrhea.

Tell your HCP if you have liver problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.


AMITIZA (lubiprostone) 24 mcg capsules twice daily is approved to treat Chronic Idiopathic Constipation (CIC) in adults. "Idiopathic" means the cause of the constipation is unknown and not due to an underlying illness or medication. AMITIZA 24 mcg twice daily is also approved to treat constipation caused by opioids, a type of prescription pain medicine, in adults with chronic, non-cancer pain. The effectiveness of AMITIZA has not been established if you are taking a diphenylheptane opioid (e.g., methadone). AMITIZA 8 mcg capsules twice daily is approved to treat Irritable Bowel Syndrome with Constipation (IBS-C) in women 18 years of age and older.

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