Real Patients Share Their Experience

Meet Susie, Suzanne, and Miho. Like you, they are all too familiar with the experience of chronic constipation. Watch their videos to hear their stories, and find out how AMITIZA helped. Individual results may vary.

Individual results may vary.

06:24

Get to know these real patients.

Individual results may vary.

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Hear Susie discuss her CIC.

Hear Susie discuss her CIC.

Individual results may vary.

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Hear Suzanne talk about her IBS-C.

Hear Suzanne talk about her IBS-C.

Individual results may vary.

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Hear Miho talk about her CIC.

Hear Miho talk about her CIC.

Individual results may vary.

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Video Transcript

SUSIE: I feel like I have been dealing with chronic constipation for a very long time.

SUPER: Chronic Idiopathic Constipation may include the following (if experienced for the last 3 months, with symptoms starting at least 6 months ago):

SUSIE: It’s hard to remember a time in my adult life when I didn’t feel like I was dealing with constipation.

SUPER: Any 2 or more of the following symptoms: straining, lumpy or hard stools, feeling like your bowel is never completely empty, feeling like your bowel is blocked,...

MIHO: I’ve never felt comfortable talking about personal issues like chronic constipation. It’s just so private.

SUPER: ...fewer than 3 bowel movements per week, need to manually pass a bowel movement. And loose stools are rarely present without the use of laxatives.

MIHO: Sometimes I couldn’t go to the bathroom for several days. And when I did go, I felt like I was straining at times.

SUPER: “Idiopathic” means the cause of the constipation is unknown and not due to an underlying illness or medication.

SUZANNE: It’s been quite a while since I first started to feel symptoms that I later would find out were related to Irritable Bowel Syndrome, or IBS with constipation.

SUPER: Irritable Bowel Syndrome with Constipation (IBS-C) may include the following (if experienced for the last 3 months, with symptoms starting at least 6 months ago):

SUZANNE: Sometimes I had stomach pain and I felt bloated. When I was able to go, I felt better.

SUPER: Re-occurring abdominal pain/discomfort at least 3 days per month in the past 3 months with 2 or more of the following:

SUZANNE: But at times I had to strain. I noticed I could only go a few times a week. I never really knew why I had these symptoms...

SUPER: Improvement with a bowel movement, changes in the number of bowel movements, changes in stool appearance, and...

SUZANNE: ...and I didn’t know what to do about them. Sometimes it was stress that triggered it. Sometimes there was no reason at all.

SUPER: ...hard/lumpy stools at least 25% of the time and loose/watery stools in less than 25% of bowel movements (without the use of antidiarrheals or laxatives).

SUSIE: Sometimes, I would get this “full, bloated” feeling. And 3 or more days within a week without going was not uncommon for me.

SUPER: Once your healthcare provider has a clear understanding of your symptoms, they can give a diagnosis.

MIHO: I’ve tried laxatives and other over-the-counter treatments, and they helped. But my symptoms often returned. I went to my internal medicine doctor, and she was very supportive. She was easy to talk to, and she was willing to listen to my concerns. When she diagnosed me with chronic idiopathic constipation, it was reassuring…this condition had a name and there were ways that could help treat it.

SUSIE: The gastroenterologist also said that a prescription medicine called AMITIZA, or lubiprostone, might be able to help me.

SUPER: Individual results may vary. AMITIZA (lubiprostone) 24 mcg capsules twice daily is approved to treat Chronic Idiopathic Constipation (CIC) in adults.

SUZANNE: So I talked to a gastroenterologist about what was going on. He recommended that I try AMITIZA or lubiprostone. He explained that AMITIZA wasn’t a laxative or fiber. He told me that it could help treat IBS with constipation.

SUPER: Individual results may vary. AMITIZA (lubiprostone) 8 mcg capsules twice daily is approved to treat Irritable Bowel Syndrome with Constipation (IBS-C) in women ≥18 years of age and older.

SUSIE: After a week or so, I began to see improvement in my bowel movements. I was going to the bathroom more often, and I wasn’t straining as much.

SUPER: Individual results may vary. In two 4-week CIC clinical studies, people taking AMITIZA averaged 5 to 6 bowel movements per week, versus 3 to 4 without AMITIZA.

MIHO: After taking it for a few weeks, I told my doctor that I thought AMITIZA was helping to improve my chronic constipation symptoms.

SUPER: Individual results may vary. AMITIZA improves abdominal bloating, abdominal discomfort, stool consistency, straining, and constipation severity associated with CIC.

SUZANNE: After taking AMITIZA, I noticed that my symptoms were improving. I was starting to feel better than I had before.

SUPER: Individual results may vary. Overall symptoms of IBS-C include abdominal discomfort, abdominal pain, bowel habits, and other IBS symptoms.

MIHO: What would I say to people who have chronic idiopathic constipation? Talk to your doctor like I did. Ask if AMITIZA is right for you.

SUPER: Individual results may vary. The need for continued therapy should be periodically assessed with your healthcare provider.

SUZANNE: If anyone I knew had IBS-C, and if there were anything I could say to encourage them to go see their doctor, I would say it. You owe it to yourself.

SUPER: Individual results may vary.

VOICEOVER AND SUPER: Indications. AMITIZA (lubiprostone) 24 microgram capsules twice daily is approved to treat Chronic Idiopathic Constipation (CIC) in adults. “Idiopathic” means the cause of the constipation is unknown and not due to an underlying illness or medication. AMITIZA 8 microgram capsules twice daily is approved to treat Irritable Bowel Syndrome with Constipation (IBS-C) in women ≥18 years of age and older.

Important Safety Information. AMITIZA (lubiprostone) is not for everyone. If you know or suspect you have a bowel blockage, do not take AMITIZA. If you are unsure, your healthcare provider (HCP) should evaluate your condition before starting AMITIZA.

Some patients taking AMITIZA may experience nausea. Take AMITIZA with food and water to reduce the occurrence of nausea.

Do not take AMITIZA if you have severe diarrhea. Some patients taking AMITIZA may experience diarrhea. If your diarrhea becomes severe, stop taking AMITIZA and tell your HCP.

Patients may experience fainting and low blood pressure after taking the first dose or repeated doses of AMITIZA. Stop taking AMITIZA and tell your HCP if these reactions occur. Symptoms usually go away before the next dose but may recur with repeated use. Tell your HCP if you are taking any medications to lower blood pressure. Other side effects such as diarrhea or vomiting may increase the risk of fainting and low blood pressure.

Within an hour of taking AMITIZA, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use. Tell your HCP if you experience these symptoms.

The most common side effects of taking AMITIZA 24 micrograms twice daily for CIC are nausea, diarrhea, headache, abdominal pain, abdominal distension, and gas. The most common side effects of taking AMITIZA 8 micrograms twice daily for IBS-C are nausea, diarrhea, and abdominal pain. These are not all the side effects associated with AMITIZA.

Tell your HCP if you are taking a diphenylheptane opioid (e.g., methadone).

AMITIZA has not been studied in pregnant women. Based on animal studies, AMITIZA may cause fetal harm. AMITIZA should only be used during pregnancy if the potential benefits justify the potential risk to the fetus. If you are pregnant or become pregnant while being treated with AMITIZA, talk to your HCP to evaluate the risks to the fetus. Tell your HCP if you are nursing and monitor infants for diarrhea.

Tell your HCP if you have liver problems.

Please see the accompanying complete Prescribing Information for AMITIZA. The link to the Prescribing Information can be found at the top of this page.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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Talking to your doctor

Sharing your history with chronic constipation helps your doctor find the treatment plan that is right for you. The Doctor Discussion Guide can help make the conversation more productive.

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Taking AMITIZA

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Uses & Important Safety Information

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AMITIZA is used for 3 types of chronic constipation: CIC in adults, OIC in adults with chronic pain that is not caused by active cancer, and IBS-C in women ≥ 18 years. Effectiveness in patients taking methadone has not been established.

Important Safety Information

AMITIZA (lubiprostone) is not for everyone. If you know or suspect you have a bowel blockage, do not take AMITIZA. If you are unsure, your healthcare provider (HCP) should evaluate your condition before starting AMITIZA.

Some patients taking AMITIZA may experience nausea. Take AMITIZA with food and water to reduce the occurrence of nausea.

Do not take AMITIZA if you have severe diarrhea. Some patients taking AMITIZA may experience diarrhea. If your diarrhea becomes severe, stop taking AMITIZA and tell your HCP.

Patients may experience fainting and low blood pressure after taking the first dose or repeated doses of AMITIZA. Stop taking AMITIZA and tell your HCP if these reactions occur. Symptoms usually go away before the next dose but may recur with repeated use. Tell your HCP if you are taking any medications to lower blood pressure. Other side effects such as diarrhea or vomiting may increase the risk of fainting and low blood pressure.

Within an hour of taking AMITIZA, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use. Tell your HCP if you experience these symptoms.

The most common side effects of taking AMITIZA 24 mcg twice daily for CIC are nausea, diarrhea, headache, abdominal pain, abdominal distension, and gas. The most common side effects of taking AMITIZA 24 mcg twice daily for Opioid-Induced Constipation are nausea and diarrhea. The most common side effects of taking AMITIZA 8 mcg twice daily for IBS-C are nausea, diarrhea, and abdominal pain. These are not all the side effects associated with AMITIZA.

Tell your HCP if you are taking a diphenylheptane opioid (e.g., methadone).

AMITIZA has not been studied in pregnant women. Based on animal studies, AMITIZA may cause fetal harm. AMITIZA should only be used during pregnancy if the potential benefits justify the potential risk to the fetus. If you are pregnant or become pregnant while being treated with AMITIZA, talk to your HCP to evaluate the risks to the fetus. Tell your HCP if you are nursing and monitor infants for diarrhea.

Tell your HCP if you have liver problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Indications

AMITIZA (lubiprostone) 24 mcg capsules twice daily is approved to treat Chronic Idiopathic Constipation (CIC) in adults. “Idiopathic” means the cause of the constipation is unknown and not due to an underlying illness or medication. AMITIZA 24 mcg twice daily is also approved to treat constipation caused by opioids, a type of prescription pain medicine, in adults with chronic pain that is not caused by active cancer. The effectiveness of AMITIZA has not been established if you are taking a diphenylheptane opioid (e.g., methadone). AMITIZA 8 mcg capsules twice daily is approved to treat Irritable Bowel Syndrome with Constipation (IBS-C) in women ≥ 18 years of age.

Please click here for complete Prescribing Information.

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