The AMITIZA Savings Program can help support your treatment plan. When you sign up, you’ll get emails full of tips and information to help you manage chronic constipation. Plus, eligible patients can pay $0* for their prescriptions every month.

With the AMITIZA Savings Card:

  • Patients can save up to $75 on 30-day prescriptions
  • Appropriate patients can save up to $225 on 90-day prescriptions

*Subject to maximum benefit. You must meet Eligibility Requirements.

Patient Financial Assistance Within Reach

Additional financial assistance

Takeda understands that some patients may have financial situations that make it difficult to pay for their prescriptions. Help At Hand provides assistance to patients with no insurance or those who do not have enough insurance and need help getting their Takeda medicines. Please call 1-800-830-9159 or visit to learn more.


Questions about saving on AMITIZA

Can the AMITIZA Savings Program help
with my co‑pay?

Yes. Patients can save up to $75 on 30-day prescriptions, and appropriate patients can save up to $225 on 90-day prescriptions.*

*Subject to maximum benefit. You must meet Eligibility Requirements.

If I’m ineligible for savings, can I still get support from the AMITIZA Savings Program?

Yes. If you are ineligible for the savings card you can still register for the AMITIZA Savings Program to receive emails with information about AMITIZA and tips to help manage chronic constipation.

Are there any assistance programs available to help me get AMITIZA?

Help At Hand provides options for receiving free or low-cost medicines. Visit to learn more.

I've already paid for my prescription of AMITIZA. Is there a mail-in rebate available?

Patient mail-in rebate forms and information on how to complete and submit them are available at You may also request one by calling 1-866-279-8995.

Get to know
real patients

Find out what real patients have to say about their experience with chronic constipation and AMITIZA.

See their stories


Find out what to expect when taking AMITIZA.

Learn more

Helpful tools
& resources

These guides can help you prepare for your next doctor visit and track how you're doing with AMITIZA.

Download the guides

Uses & Important Safety Information

AMITIZA is for CIC in adults, OIC in adults with chronic, non-cancer pain, and IBS-C in women ≥ 18 years. Effectiveness in patients taking methadone has not been established.

Important Safety Information

AMITIZA (lubiprostone) is not for everyone. If you know or suspect you have a bowel blockage, do not take AMITIZA. If you are unsure, your healthcare provider (HCP) should evaluate your condition before starting AMITIZA. You should not take AMITIZA if you have severe diarrhea.

Some patients taking AMITIZA may experience nausea or diarrhea. If nausea occurs, take AMITIZA with food and water, if it becomes severe, tell your HCP. If your diarrhea becomes severe, stop taking AMITIZA and tell your HCP.

Within an hour of taking AMITIZA, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use. Tell your HCP if you experience these symptoms.

The most common side effects of taking AMITIZA (24 mcg) twice daily are nausea, diarrhea, headache, abdominal pain, abdominal distension, and gas for patients treated for CIC; nausea and diarrhea for patients treated for Opioid-Induced Constipation. The most common side effects of taking AMITIZA (8 mcg) twice daily for IBS-C are nausea, diarrhea, and abdominal pain. These are not all the side effects associated with AMITIZA.

Tell your HCP if you are taking a diphenylheptane opioid (e.g. methadone).

AMITIZA has not been studied in pregnant women. Based on animal studies, AMITIZA may cause fetal harm. AMITIZA should only be used during pregnancy if the potential benefits justify the potential risk to the fetus. If you are pregnant or become pregnant while being treated with AMITIZA, talk to your HCP to evaluate the risks to the fetus. Tell your HCP if you are nursing and monitor infants for diarrhea.

Tell your HCP if you have liver problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.


AMITIZA (lubiprostone) 24 mcg capsules twice daily is approved to treat Chronic Idiopathic Constipation (CIC) in adults. “Idiopathic” means the cause of the constipation is unknown and not due to an underlying illness or medication. AMITIZA 24 mcg twice daily is also approved to treat constipation caused by opioids (OIC), a type of prescription pain medicine, in adults with chronic, non-cancer pain. The effectiveness of AMITIZA has not been established if you are taking a diphenylheptane opioid (e.g., methadone). AMITIZA 8 mcg capsules twice daily is approved to treat Irritable Bowel Syndrome with Constipation (IBS-C) in women 18 years of age and older.

Please click here for complete Prescribing Information.